demyelination

XPro1595 may promote myelin restoration, new mouse study finds

INmune Bio‘s experimental therapy XPro1595 may promote myelin restoration through the activation of two types of nervous system support cells, according to new data that may lead to novel treatment strategies for multiple sclerosis (MS) and other neurodegenerative disorders. The findings highlight the activation of microglia, key…

Ocrevus Outperforms Rebif in Preventing Myelin Loss in Trial

Two years of treatment with Ocrevus (ocrelizumab) outperformed Rebif (interferon beta-1a) at preventing myelin loss in people with relapsing multiple sclerosis (MS), according to a new analysis of data from the OPERA II clinical trial. Ocrevus’ protection against demyelination was observed both in MS lesions,…

Researchers Distinguish Remyelinated Brain Lesions Via MRI

An MRI technique called quantitative susceptibility mapping (QSM) can be used to accurately identify remyelinated brain lesions in people with multiple sclerosis (MS), a research team has discovered. Remyelinated lesions are those in which the myelin sheath ā€” the protective coating around nerve fibers that is progressively lost…

Proteins Called Tenascins Found to Block Myelin Repair in Mouse Model

Proteins called tenascins block the regeneration of myelin by modulating the activity of oligodendrocytes, myelin-making cells of the central nervous system, a study in mouse modelsĀ indicates. “Our research results open up new therapeutic approaches for the treatment of demyelinating diseases such as multiple sclerosis,” Juliane Bauch, a researcher at Ruhr-University…

MS Advocacy Gives Me Strength and Purpose

I want to help in any way I possibly can. My lonely confusion in the early days after being diagnosed with aggressive relapsing-remitting multiple sclerosis was mentally and physically paralyzing. However, this column isnā€™t about how ā€œHurricane MSā€ battered my body. Instead, it’s about why I chose to…

Need to Know: What Is a Tremor?

Editorā€™s note: ā€œNeed to Knowā€ is a series inspired by common forum questions and comments from readers. Have a comment or question about MS? Visit our forum.Ā This weekā€™s question is inspired by the forum topicĀ ā€œTremors Caused by MSā€Ā from April 30, 2018. Whatā€™s shaking? If you…